Abstract
Serine proteases are important components of the immune system, playing a role in many processes including migration, phagocytosis and elimination of virally infected and cancerous cells. Members of the serpin superfamily regulate the activity of these proteases to limit tissue damage and unwarranted cell death. This review focuses on the role of intracellular (clade B) serpins in maintaining viability of both innate and adaptive immune cells.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Humans
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Immune System / enzymology*
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Immune System / immunology*
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Immune System / pathology
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Inflammation Mediators / chemistry
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Inflammation Mediators / classification
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Inflammation Mediators / physiology
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Multigene Family*
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Serine Proteinase Inhibitors / chemistry
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Serine Proteinase Inhibitors / classification
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Serine Proteinase Inhibitors / genetics
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Serine Proteinase Inhibitors / physiology*
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Serpins / chemistry
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Serpins / classification
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Serpins / genetics
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Serpins / physiology*
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Vertebrates / genetics
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Vertebrates / immunology*
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Vertebrates / metabolism*
Substances
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Inflammation Mediators
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Serine Proteinase Inhibitors
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Serpins