Abstract
In this preliminary study, 16 psychotropic-naïve pediatric patients with obsessive-compulsive disorder (OCD) were studied using magnetic resonance spectroscopy (MRS) and genotyped for six candidate polymorphisms in two glutamate system genes. A significant association was identified between the rs1019385 polymorphism of the glutamate receptor, ionotropic, N-methyl-d-aspartate 2B (GRIN2B) and decreased anterior cingulate cortex (ACC) glutamatergic concentration (Glx) but not with occipital Glx. These results suggest that GRIN2B may be associated with Glx in the ACC, a region consistently implicated in OCD.
Publication types
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Comparative Study
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Age Factors
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Brain
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Child
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Female
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Genetic Variation
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Genotype
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Glutamic Acid / analysis
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Glutamic Acid / metabolism*
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Gyrus Cinguli / metabolism*
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Humans
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Magnetic Resonance Spectroscopy
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Male
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Obsessive-Compulsive Disorder / genetics*
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Obsessive-Compulsive Disorder / metabolism
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Occipital Lobe / metabolism
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Polymorphism, Genetic
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Receptors, N-Methyl-D-Aspartate / genetics*
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Receptors, N-Methyl-D-Aspartate / metabolism
Substances
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NR2B NMDA receptor
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Receptors, N-Methyl-D-Aspartate
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Glutamic Acid