Abstract
We show that phenoxyauxin herbicides and lipid-lowering fibrates inhibit human but not rodent T1R3. T1R3 as a coreceptor in taste cells responds to sweet compounds and amino acids; in endocrine cells of gut and pancreas T1R3 contributes to glucose sensing. Thus, certain effects of fibrates in treating hyperlipidemia and type II diabetes may be via actions on T1R3. Likewise, phenoxy herbicides may have adverse metabolic effects in humans that would have gone undetected in studies on rodents.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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2,4-Dichlorophenoxyacetic Acid / analogs & derivatives
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2,4-Dichlorophenoxyacetic Acid / chemistry
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2,4-Dichlorophenoxyacetic Acid / pharmacology
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Animals
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Benzene Derivatives / chemistry
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Benzene Derivatives / pharmacology*
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Bezafibrate / chemistry
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Bezafibrate / pharmacology
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Cell Line
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Cercopithecidae
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Clofibric Acid / chemistry
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Clofibric Acid / pharmacology*
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Gemfibrozil / chemistry
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Gemfibrozil / pharmacology
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Herbicides / chemistry
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Herbicides / pharmacology*
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Humans
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Hypolipidemic Agents / chemistry
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Hypolipidemic Agents / pharmacology*
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Indoleacetic Acids / chemistry
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Indoleacetic Acids / pharmacology
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Mice
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Protein Subunits / antagonists & inhibitors
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Protein Subunits / genetics
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Receptors, G-Protein-Coupled / antagonists & inhibitors*
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Receptors, G-Protein-Coupled / genetics
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Recombinant Fusion Proteins / antagonists & inhibitors
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Recombinant Fusion Proteins / genetics
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Structure-Activity Relationship
Substances
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Benzene Derivatives
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Herbicides
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Hypolipidemic Agents
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Indoleacetic Acids
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Protein Subunits
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Receptors, G-Protein-Coupled
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Recombinant Fusion Proteins
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taste receptors, type 1
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2,4-Dichlorophenoxyacetic Acid
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Clofibric Acid
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dichlorprop
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Gemfibrozil
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Bezafibrate
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lactisole