Abstract
The central proposition advanced herein is that complex target oriented synthesis, enabled by historic advances in methodology, has enormously expanded the scope of the possible. Accordingly, natural products, a proven long-term source of pharma discovery, re-emerge as potentially valuable elements for synthesis-driven pharma exploitation.
MeSH terms
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Animals
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Biological Products* / chemical synthesis
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Biological Products* / chemistry
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Biological Products* / pharmacology
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Drug Discovery*
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Epothilones / chemical synthesis
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Epothilones / chemistry
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Epothilones / pharmacology
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Macrolides / chemical synthesis
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Macrolides / chemistry
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Macrolides / pharmacology
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Mice
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Molecular Structure
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Myxococcales / chemistry
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Piperidones / chemical synthesis
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Piperidones / chemistry
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Piperidones / pharmacology
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Streptomyces / chemistry
Substances
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Biological Products
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Epothilones
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Macrolides
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Piperidones
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migrastatin