The control of kainic acid-induced status epilepticus

Katia Vermoesen; Ilse Smolders; Ann Massie; Yvette Michotte; Ralph Clinckers

doi:10.1016/j.eplepsyres.2010.04.001

The control of kainic acid-induced status epilepticus

Epilepsy Res. 2010 Jun;90(1-2):164-6. doi: 10.1016/j.eplepsyres.2010.04.001.

Authors

Katia Vermoesen¹, Ilse Smolders, Ann Massie, Yvette Michotte, Ralph Clinckers

Affiliation

¹ Department of Pharmaceutical Chemistry and Drug Analysis, Research Group Experimental Pharmacology, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.

PMID: 20434312
DOI: 10.1016/j.eplepsyres.2010.04.001

Abstract

In the present study the effectiveness of different diazepam-ketamine combinations to control kainic acid-induced status epilepticus in rats was evaluated. We show that electrographic monitoring is mandatory to enable reliable assessment of status epilepticus control as the number of false positives is extremely high when status epilepticus control is only behaviourally assessed. Diazepam and ketamine synergistically blocked all electrographical seizure activity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anticonvulsants / therapeutic use*
Diazepam / therapeutic use*
Disease Models, Animal
Dose-Response Relationship, Drug
Drug Synergism
Electroencephalography / methods
Excitatory Amino Acid Antagonists / therapeutic use*
Kainic Acid
Ketamine / therapeutic use*
Male
Rats
Rats, Wistar
Status Epilepticus / chemically induced
Status Epilepticus / drug therapy*

Substances

Anticonvulsants
Excitatory Amino Acid Antagonists
Ketamine
Diazepam
Kainic Acid