Posttraumatic mossy fiber sprouting is related to the degree of cortical damage in three mouse strains

Epilepsy Res. 2012 Mar;99(1-2):167-70. doi: 10.1016/j.eplepsyres.2011.10.011. Epub 2011 Nov 1.

Abstract

Controlled cortical impact injury was used to examine relationships between focal posttraumatic cortical damage and mossy fiber sprouting (MFS) in the dentate gyrus in three mouse strains. Posttraumatic MFS was more robust when cortical injury impinged upon the hippocampus, versus contusions restricted to neocortex, and was qualitatively similar among CD-1, C57BL/6, and FVB/N background strains. Impact parameters influencing injury severity may be critical in reproducing epilepsy-related changes in neurotrauma models.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Brain Injuries / complications
  • Brain Injuries / genetics*
  • Brain Injuries / pathology*
  • Cerebral Cortex / pathology*
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred Strains
  • Mossy Fibers, Hippocampal / pathology*
  • Species Specificity