This study investigates the presence of drugs in apocrine sweat. The samples were collected from the axillary perspiration of 25 hs. The determination of the drugs was performed by radioimmunoassay. The concentrations measured represent the sum of drugs and there metabolites. Measurable drugs concentrations of THC, benzodiazepine, cocaine, barbiturate, morphine, methadone and cotinine were found in all samples. The presence of the drugs in the sweat was manifested also by GC/MS.