Abstract
Two distinct Ca currents may be recorded from guinea pig hippocampal CA1 neuronal somata: a non-inactivating (persistent) current and a rapidly inactivating (transient) current. Nimodipine, a 'calcium antagonist', reduced both Ca currents though the transient current was somewhat less sensitive than the persistent current. BAY K 8644, a 'calcium agonist' enhanced the persistent current and shifted the activation threshold for this current to more negative potentials. BAY K 8644 also enhanced the transient Ca current though the effect was very variable. The results demonstrate that Ca channels in hippocampal CA1 neurones possess a dihydropyridine receptor in common with Ca channels in other tissues.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester / pharmacology*
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Animals
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Calcium / metabolism*
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Calcium Channels
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Female
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Guinea Pigs
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Hippocampus / analysis
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Hippocampus / drug effects*
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In Vitro Techniques
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Ion Channels / analysis
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Ion Channels / drug effects*
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Male
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Membrane Potentials / drug effects
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Neural Conduction / drug effects
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Nimodipine / pharmacology*
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Receptors, Nicotinic / analysis
Substances
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Calcium Channels
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Ion Channels
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Receptors, Nicotinic
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Nimodipine
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3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester
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Calcium