Abstract
Subunits of guanine nucleotide regulatory proteins purified from bovine cerebral cortex were used to perfuse the intracellular surface of excised patches of chick embryonic atrial cells. Single-channel current measurements unexpectedly indicate that the beta gamma, and not the alpha subunits, are responsible for activating the muscarinic-gated potassium channel.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Chick Embryo
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Electric Conductivity
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GTP-Binding Proteins / physiology*
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Guanosine 5'-O-(3-Thiotriphosphate)
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Guanosine Triphosphate / analogs & derivatives
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Guanosine Triphosphate / pharmacology
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Guanylyl Imidodiphosphate / pharmacology
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Heart / physiology*
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In Vitro Techniques
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Ion Channels / physiology*
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Macromolecular Substances
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Magnesium / pharmacology
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Potassium / physiology*
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Receptors, Muscarinic / physiology*
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Structure-Activity Relationship
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Thionucleotides / pharmacology
Substances
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Ion Channels
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Macromolecular Substances
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Receptors, Muscarinic
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Thionucleotides
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Guanylyl Imidodiphosphate
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Guanosine 5'-O-(3-Thiotriphosphate)
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Guanosine Triphosphate
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GTP-Binding Proteins
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Magnesium
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Potassium