Activation of the mas oncogene during transfection of monoblastic cell line DNA

J W Janssen; A C Steenvoorden; M Schmidtberger; C R Bartram

Activation of the mas oncogene during transfection of monoblastic cell line DNA

Leukemia. 1988 May;2(5):318-20.

Authors

J W Janssen¹, A C Steenvoorden, M Schmidtberger, C R Bartram

Affiliation

¹ Departments of Pediatrics II, University of Ulm, F.R.G.

PMID: 2453759

Abstract

Using the tumorigenicity assay, we observed an activation of the mas oncogene during transfection of human acute myelocytic leukemia (CTV-2) DNA. Respective transfectants contained amplified mas sequences characterized by rearrangements in 5' and 3' noncoding regions that were transcribed into a 3.3 kb mas RNA species. Our data represent the second report on activation of the mas gene.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
DNA Restriction Enzymes / metabolism
DNA, Neoplasm / metabolism*
Gene Expression Regulation*
Humans
Leukemia, Myeloid, Acute / genetics*
Mice
Mice, Nude
Oncogenes*
Poly A / analysis
RNA / analysis
RNA, Messenger
Transfection*

Substances

DNA, Neoplasm
RNA, Messenger
Poly A
RNA
DNA Restriction Enzymes