GPCR signaling along the endocytic pathway

Roshanak Irannejad; Mark von Zastrow

doi:10.1016/j.ceb.2013.10.003

GPCR signaling along the endocytic pathway

Curr Opin Cell Biol. 2014 Apr:27:109-16. doi: 10.1016/j.ceb.2013.10.003. Epub 2013 Dec 28.

Authors

Roshanak Irannejad¹, Mark von Zastrow²

Affiliations

¹ Department of Psychiatry, University of California, San Francisco School of Medicine, 600 16th Street, San Francisco, CA 94158-2140, USA; Department of Cellular & Molecular Pharmacology, University of California, San Francisco School of Medicine, 600 16th Street, San Francisco, CA 94158-2140, USA.
² Department of Psychiatry, University of California, San Francisco School of Medicine, 600 16th Street, San Francisco, CA 94158-2140, USA; Department of Cellular & Molecular Pharmacology, University of California, San Francisco School of Medicine, 600 16th Street, San Francisco, CA 94158-2140, USA. Electronic address: mark.vonzastrow@ucsf.edu.

Abstract

Many G protein-coupled receptors (GPCRs) internalize after agonist-induced activation. While endocytosis has long been associated with homeostatic attenuation of cellular responsiveness, accumulating evidence from study of a wide range of eukaryotes reveals that the endocytic pathway also contributes to generating receptor-initiated signals themselves. Here we review recent progress in this area, discussing primarily but not exclusively GPCR signaling in mammalian cells.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Endocytosis*
Endosomes / metabolism
Humans
Intracellular Membranes / metabolism
Receptors, G-Protein-Coupled / metabolism*
Signal Transduction*

Substances

Receptors, G-Protein-Coupled

Abstract

Publication types

MeSH terms

Substances

Grants and funding