Abstract
The calcium antagonists nimodipine and dantrolene were compared with diazepam in an animal model of tolerance and physical dependence upon ethanol. Nimodipine and dantrolene were both effective in suppressing withdrawal tremors but diazepam was clearly superior to both agents. These results suggest that the ethanol withdrawal syndrome is only partially mediated by increased calcium flux.
MeSH terms
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Animals
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Brain Chemistry / drug effects
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Calcium Channel Blockers / pharmacology*
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Dantrolene / pharmacology
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Diazepam / pharmacology*
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Ethanol / pharmacology*
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Male
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Nimodipine / administration & dosage
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Nimodipine / pharmacokinetics
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Nimodipine / pharmacology
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Rats
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Rats, Inbred Strains
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Substance Withdrawal Syndrome / drug therapy*
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Substance Withdrawal Syndrome / physiopathology
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Tremor / drug therapy*
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Tremor / physiopathology
Substances
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Calcium Channel Blockers
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Ethanol
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Nimodipine
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Dantrolene
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Diazepam