The kinome 'at large' in cancer

Emmy D G Fleuren; Luxi Zhang; Jianmin Wu; Roger J Daly

doi:10.1038/nrc.2015.18

The kinome 'at large' in cancer

Nat Rev Cancer. 2016 Feb;16(2):83-98. doi: 10.1038/nrc.2015.18.

Authors

Emmy D G Fleuren¹, Luxi Zhang^{2

3

4}, Jianmin Wu⁵, Roger J Daly^{2

3}

Affiliations

¹ Department of Medical Oncology, Radboud University Medical Centre, Geert Grooteplein-Zuid 10, 6525 GA Nijmegen, The Netherlands.
² Cancer Program, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.
³ Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia.
⁴ University of New South Wales, Sydney, New South Wales 2052, Australia.
⁵ Cancer Division, Kinghorn Cancer Centre, Garvan Institute of Medical Research, 370 Victoria Street, Sydney, New South Wales 2010, Australia.

PMID: 26822576
DOI: 10.1038/nrc.2015.18

Abstract

Over the past decade, rapid advances in genomics, proteomics and functional genomics technologies that enable in-depth interrogation of cancer genomes and proteomes and high-throughput analysis of gene function have enabled characterization of the kinome 'at large' in human cancers, providing crucial insights into how members of the protein kinase superfamily are dysregulated in malignancy, the context-dependent functional role of specific kinases in cancer and how kinome remodelling modulates sensitivity to anticancer drugs. The power of these complementary approaches, and the insights gained from them, form the basis of this Analysis article.

Publication types

Review

MeSH terms

Gene Expression Regulation, Enzymologic
Gene Expression Regulation, Neoplastic
High-Throughput Screening Assays
Histone Acetyltransferases / genetics
Histone Acetyltransferases / metabolism
Humans
Molecular Targeted Therapy / methods
Mutation
NIMA-Related Kinases
Neoplasms / enzymology*
Neoplasms / genetics
Neoplasms / metabolism
Protein Kinases / genetics*
Protein Kinases / metabolism*
Protein Serine-Threonine Kinases / genetics
Protein Serine-Threonine Kinases / metabolism
Proteomics / methods
TATA-Binding Protein Associated Factors / genetics
TATA-Binding Protein Associated Factors / metabolism
Transcription Factor TFIID / genetics
Transcription Factor TFIID / metabolism

Substances

TATA-Binding Protein Associated Factors
Transcription Factor TFIID
Histone Acetyltransferases
Protein Kinases
NEK9 protein, human
NIMA-Related Kinases
Protein Serine-Threonine Kinases
TATA-binding protein associated factor 250 kDa