Effect of PK 11195, an antagonist of benzodiazepine receptors, on platelet aggregation in a model of anxiety in the rat

Gen Pharmacol. 1988;19(4):573-7. doi: 10.1016/0306-3623(88)90166-8.

Abstract

1. Anxiety induced by forced swimming increases maximal intensity (h) of platelet aggregation (PAG) and time to reach it (t). 2. PK 11195 pretreatment (12.5 and 25 mg/kg) reverses anxiety-induced PAG changes. At 6.25 mg/kg it inhibits PAG. 3. Changes induced by anxiety on PAG may be mediated by peripheral-benzodiazepine receptors.

MeSH terms

  • Animals
  • Anxiety / blood*
  • Female
  • Isoquinolines / pharmacology*
  • Male
  • Platelet Aggregation / drug effects*
  • Rats
  • Rats, Inbred Strains
  • Receptors, GABA-A / metabolism*

Substances

  • Isoquinolines
  • Receptors, GABA-A
  • PK 11195