Transporters in Drug Development: 2018 ITC Recommendations for Transporters of Emerging Clinical Importance

Clin Pharmacol Ther. 2018 Nov;104(5):890-899. doi: 10.1002/cpt.1112. Epub 2018 Aug 8.

Abstract

This white paper provides updated International Transporter Consortium (ITC) recommendations on transporters that are important in drug development following the 3rd ITC workshop. New additions include prospective evaluation of organic cation transporter 1 (OCT1) and retrospective evaluation of organic anion transporting polypeptide (OATP)2B1 because of their important roles in drug absorption, disposition, and effects. For the first time, the ITC underscores the importance of transporters involved in drug-induced vitamin deficiency (THTR2) and those involved in the disposition of biomarkers of organ function (OAT2 and bile acid transporters).

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Drug Development / methods*
  • Drug Interactions
  • Humans
  • Membrane Transport Modulators / metabolism
  • Membrane Transport Modulators / pharmacology*
  • Membrane Transport Proteins / drug effects*
  • Membrane Transport Proteins / metabolism*
  • Models, Biological
  • Pharmaceutical Preparations / metabolism*
  • Pharmacokinetics*
  • Risk Assessment

Substances

  • Membrane Transport Modulators
  • Membrane Transport Proteins
  • Pharmaceutical Preparations