Abstract
Sixteen calcium channel inhibitors (CCI's) were tested in a model utilizing amphetamine-induced behavioral stimulation in mice. Nifedipine, flunarizine and possibly PY 108-068 were effective in blocking amphetamine-induced locomotor stimulation. Verapamil, diltiazem and many other CCI's were ineffective in this experimental paradigm.
MeSH terms
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Animals
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Calcium Channel Blockers / pharmacology*
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Cinnarizine / analogs & derivatives*
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Cinnarizine / pharmacology
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Dextroamphetamine / antagonists & inhibitors*
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Dose-Response Relationship, Drug
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Flunarizine
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Mice
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Motor Activity / drug effects*
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Nifedipine / analogs & derivatives
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Nifedipine / pharmacology*
Substances
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Calcium Channel Blockers
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Cinnarizine
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Nifedipine
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darodipine
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Flunarizine
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Dextroamphetamine