Abstract
We describe a new class of drugs that selectively block serotonin M-receptors on peripheral neurones. Because of their high affinity, some of these drugs are the most potent of any pharmacological class yet reported. They have allowed the identification of three M-receptor subtypes, one of which is responsible for mediating the painful effects of serotonin in humans.
MeSH terms
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Animals
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Bradykinin / pharmacology
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Cerebral Cortex
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Female
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Guinea Pigs
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Heart / innervation
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Humans
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Ileum
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Indoles / metabolism
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Indoles / pharmacology
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Male
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Muscle, Smooth / innervation
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Neurons / metabolism*
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Pain / chemically induced
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Peripheral Nerves / metabolism
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Rabbits
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Rats
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Receptors, Serotonin / metabolism
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Receptors, Serotonin / physiology*
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Serotonin / analogs & derivatives
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Serotonin / metabolism
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Serotonin / pharmacology
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Tropisetron
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Vagus Nerve
Substances
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Indoles
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Receptors, Serotonin
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alpha-methylserotonin
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Serotonin
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Tropisetron
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2-methyl-5-HT
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Bradykinin