Sulphur-methylene isosterism in the development of metiamide, a new histamine H2-receptor antagonist

Nature. 1974 Mar 1;248(5443):65-7. doi: 10.1038/248065a0.
No abstract available

MeSH terms

  • Animals
  • Binding, Competitive
  • Female
  • Histamine / metabolism
  • Histamine H1 Antagonists / metabolism
  • Histamine H1 Antagonists / pharmacology*
  • Hydrogen-Ion Concentration
  • Imidazoles / metabolism
  • Imidazoles / pharmacology
  • Kinetics
  • Myocardium / metabolism
  • Receptors, Drug / drug effects*
  • Stereoisomerism
  • Structure-Activity Relationship
  • Sulfides / metabolism
  • Sulfides / pharmacology
  • Thiourea / metabolism
  • Thiourea / pharmacology*
  • Uterus / metabolism

Substances

  • Histamine H1 Antagonists
  • Imidazoles
  • Receptors, Drug
  • Sulfides
  • Histamine
  • Thiourea