Abstract
Immunoreactive somatostatin, bombesin, and cholecystokinin were measured in cerebrospinal fluid of normal subjects and patients with anorexia nervosa, depression, mania, and schizophrenia. Somatostatin-like immunoreactivity was decreased in anorexic and depressed patients. Bombesin-like immunoreactivity tended to be decreased in schizophrenics. Cholecystokinin-like immunoreactivity did not differ between groups. These data suggest a possible function for neuropeptides in regulation of human behavior.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Anorexia Nervosa / cerebrospinal fluid
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Bipolar Disorder / cerebrospinal fluid
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Bombesin / cerebrospinal fluid*
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Cholecystokinin / cerebrospinal fluid*
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Depressive Disorder / cerebrospinal fluid
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Female
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Humans
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Male
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Mental Disorders / cerebrospinal fluid*
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Peptides / cerebrospinal fluid*
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Schizophrenia / cerebrospinal fluid
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Somatostatin / cerebrospinal fluid*
Substances
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Peptides
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Somatostatin
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Cholecystokinin
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Bombesin