Abstract
l-Glutamate but not methyl-D-aspartate (NMDA) or quisqualate ( Quis ) (10(-6 M) in vitro with or without preincubation increased significantly the KD value of the [3H]N-propylnorapomorphine ( [3H]NPA) binding sites by 21 and 36% respectively in striatal membranes of rat without influencing the striatal [3H]spiperone binding sites. The number of striatal [3H]NPA binding sites was not changed by l-glutamate (10(-6) and 10(-5) M) in vitro. There may thus exist interactions between striatal glutamate receptors -- not related to excitatory amino-acid receptors of the NMDA or the QUIS type -- and high affinity striatal DA receptors.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antiparkinson Agents / metabolism*
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Apomorphine / analogs & derivatives*
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Apomorphine / metabolism
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Aspartic Acid / analogs & derivatives
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Aspartic Acid / pharmacology
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Binding Sites / drug effects
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Cell Membrane / metabolism
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Corpus Striatum / metabolism*
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Corpus Striatum / ultrastructure
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Glutamates / pharmacology*
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Glutamic Acid
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Male
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N-Methylaspartate
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Neuromuscular Depolarizing Agents / pharmacology
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Oxadiazoles / pharmacology
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Quisqualic Acid
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Rats
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Rats, Inbred Strains
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Spiperone / metabolism
Substances
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Antiparkinson Agents
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Glutamates
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Neuromuscular Depolarizing Agents
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Oxadiazoles
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Aspartic Acid
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Glutamic Acid
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Spiperone
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N-n-propylnorapomorphine
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N-Methylaspartate
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Quisqualic Acid
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Apomorphine