Peptide E and other proenkephalin-derived peptides are potent kappa opiate receptor agonists

Peptides. 1983 Jul-Aug;4(4):445-9. doi: 10.1016/0196-9781(83)90047-5.

Abstract

Various proenkephalin-derived peptides such as peptide E and the bovine adrenal medulla peptides BAM-12P and BAM-22P are potent competitors on mu and kappa binding sites in guinea pig brain sections. Moreover, they are all potent agonists in the rabbit vas deferens, a specific kappa opiate receptor bioassay. As described before, dynorphin and some of its fragments are also potent kappa agonists. Our results suggest that not only prodynorphin-derived peptides could act as endogenous kappa ligands but also some proenkephalin-derived peptides such as peptide E.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenal Medulla
  • Animals
  • Biological Assay
  • Brain / metabolism*
  • Enkephalin, Methionine / analogs & derivatives
  • Enkephalin, Methionine / pharmacology
  • Enkephalins / pharmacology*
  • Guinea Pigs
  • Ileum / drug effects
  • Kinetics
  • Male
  • Mice
  • Muscle Contraction / drug effects
  • Peptides / pharmacology*
  • Protein Precursors / pharmacology
  • Receptors, Opioid / drug effects
  • Receptors, Opioid / metabolism*
  • Receptors, Opioid, kappa
  • Structure-Activity Relationship
  • Vas Deferens / drug effects

Substances

  • Enkephalins
  • Peptides
  • Protein Precursors
  • Receptors, Opioid
  • Receptors, Opioid, kappa
  • Enkephalin, Methionine
  • BAM 12P
  • BAM 22P
  • peptide E (adrenal medulla)