Abstract
The postsynaptic effect of histamine and impromidine, an H2-receptor agonist on CA1 pyramidal and dentate granule cells in the hippocampal slice of the rat is a hyperpolarization. Depolarizations are indirectly mediated. It is suggested that the hyperpolarization is generated by a conductance increase to potassium ions in the dendrites.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Electric Conductivity
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Guanidines / pharmacology
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Hippocampus / drug effects
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Hippocampus / physiology*
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Histamine / pharmacology*
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Imidazoles / pharmacology
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Impromidine
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Membrane Potentials / drug effects
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Neurons / drug effects
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Neurons / physiology*
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Rats
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Receptors, Histamine H2 / drug effects
Substances
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Guanidines
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Imidazoles
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Receptors, Histamine H2
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Histamine
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Impromidine