Abstract
In agreement with other workers we report increased [3H]R05-4864 binding in kainate-lesioned rat striatum. [3H]R05-4864 binding, a possible glial marker, was also increased in temporal cortex obtained post-mortem from patients with Alzheimer's disease. [3H]Flunitrazepam binding was decreased in these brain samples, possibly indicative of neuronal cell loss. It is suggested that the poor binding characteristics of [3H]R05-4864 in human brain samples may limit its usefulness in assessing gliosis.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Aged
-
Alzheimer Disease / metabolism*
-
Animals
-
Benzodiazepinones / metabolism*
-
Binding Sites
-
Corpus Striatum / drug effects
-
Corpus Striatum / enzymology
-
Corpus Striatum / metabolism*
-
Female
-
Flunitrazepam / metabolism*
-
Glutamate Decarboxylase / metabolism
-
Humans
-
Kainic Acid / pharmacology*
-
Male
-
Pyrrolidines / pharmacology*
-
Rats
-
Temporal Lobe / metabolism*
-
Tritium
Substances
-
Benzodiazepinones
-
Pyrrolidines
-
Tritium
-
4'-chlorodiazepam
-
Flunitrazepam
-
Glutamate Decarboxylase
-
Kainic Acid