Abstract
The ability of acetone to potentiate the toxicity of 1,1-dichloroethylene (DCE) in male rats was investigated. A biphasic potentiation of DCE-induced hepatotoxicity was observed; low doses (5 and 10 mmol/kg, p.o.) of acetone were active, whereas higher doses (15 and 30 mmol/kg) were not. Nephrotoxicity was not affected.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetone / toxicity*
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Alanine Transaminase / blood
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Animals
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Blood Urea Nitrogen
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Chemical and Drug Induced Liver Injury*
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Dichloroethylenes / toxicity*
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Drug Synergism
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Hydrocarbons, Chlorinated / toxicity*
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Kidney Diseases / chemically induced*
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Male
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Organ Size / drug effects
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Ornithine Carbamoyltransferase / blood
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Rats
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Rats, Inbred Strains
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Tetraethylammonium Compounds / metabolism
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p-Aminohippuric Acid / metabolism
Substances
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Dichloroethylenes
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Hydrocarbons, Chlorinated
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Tetraethylammonium Compounds
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Acetone
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vinylidene chloride
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Ornithine Carbamoyltransferase
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Alanine Transaminase
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p-Aminohippuric Acid