Effects of optical isomers of ketamine on excitation of cat and rat spinal neurones by amino acids and acetylcholine

Neurosci Lett. 1982 Apr 26;29(3):281-6. doi: 10.1016/0304-3940(82)90330-5.

Abstract

The (+) isomer of ketamine was approximately 3 and 1.5 times as potent as the (-) isomer in reducing excitation of rat and cat Renshaw cells by N-methylaspartate (NMA) and acetylcholine (ACh) respectively. The potency ratio of the two isomers of ketamine as NMA antagonists was similar to that obtained in anaesthetic and analgesic tests [16, 19, 25].

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylcholine / pharmacology*
  • Action Potentials / drug effects
  • Animals
  • Aspartic Acid / analogs & derivatives*
  • Aspartic Acid / pharmacology
  • Cats
  • Ketamine / pharmacology*
  • N-Methylaspartate
  • Neurons / drug effects
  • Neurons / physiology*
  • Rats
  • Spinal Cord / physiology*
  • Stereoisomerism

Substances

  • Aspartic Acid
  • N-Methylaspartate
  • Ketamine
  • Acetylcholine