Abstract
Recent cDNA cloning studies have defined four members of the opioid receptor family, i.e., delta-, mu- and kappa-subtypes, and an opioid receptor homologue for unknown ligands. In this report, we isolated and analyzed mouse genomic DNA segments containing the kappa-opioid receptor gene and a gene for the opioid receptor homologue (designated as MOR-C). The genes are closely related each other in exon-intron organization, suggesting their evolutional relationship. Using in situ hybridization, we show that the kappa-opioid receptor gene and the MOR-C gene map to mouse chromosome 1A2-3 and 2H2-4, respectively.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Biological Evolution
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Chromosome Mapping*
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Cloning, Molecular
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DNA / chemistry
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Exons
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Genomic Library
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In Situ Hybridization, Fluorescence
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Introns
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Mice / genetics*
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Molecular Sequence Data
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Nociceptin Receptor
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Receptors, Opioid / genetics*
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Receptors, Opioid, kappa / genetics*
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Restriction Mapping
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Sequence Homology
Substances
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Receptors, Opioid
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Receptors, Opioid, kappa
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DNA
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Nociceptin Receptor
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Oprl1 protein, mouse
Associated data
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GENBANK/D31663
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GENBANK/D31664
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GENBANK/D31665
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GENBANK/D31666
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GENBANK/D31667