Role of angiotensin II in extracellular matrix and transforming growth factor-beta 1 expression in hypertensive rats

Eur J Pharmacol. 1994 Sep 15;269(1):115-9. doi: 10.1016/0922-4106(94)90033-7.

Abstract

The in vivo effects of alacepril (1-[(S)-3-acetylthio-2-methylpropanoyl]- L-prolyl-L-phenylalanine), an angiotensin converting enzyme inhibitor, and SC-52458 (5-[(3,5-dibutyl-1H-1,2,4-triazol-1- yl)methyl]-2-[2-(1H-tetrazol-5-ylphenyl)]pyridine), an angiotensin AT1 receptor antagonist, were examined on the cardiac and aortic gene expressions of extracellular matrices and TGF-beta 1 in young spontaneously hypertensive rats (SHR). In SHR, types I and III collagen mRNAs were increased in the left ventricle, and in contrast, fibronectin, collagen IV, and transforming growth factor-beta 1 (TGF-beta 1) mRNAs were increased in aorta, compared with those in Wistar-Kyoto rats. All the enhanced mRNAs in both organs in SHR were significantly inhibited by the short-term treatment with the above two drugs. Thus, angiotensin AT1 receptor may play an important role in the regulation of extracellular matrices and TGF-beta 1 expressions in SHR.

Publication types

  • Comparative Study

MeSH terms

  • Angiotensin II / metabolism
  • Angiotensin Receptor Antagonists*
  • Angiotensin-Converting Enzyme Inhibitors / pharmacology*
  • Animals
  • Aorta / cytology
  • Aorta / drug effects
  • Blood Pressure / drug effects
  • Blotting, Northern
  • Captopril / analogs & derivatives*
  • Captopril / pharmacology
  • Collagen / genetics
  • Collagen / metabolism
  • Extracellular Matrix / drug effects
  • Extracellular Matrix / genetics
  • Extracellular Matrix / metabolism
  • Gene Expression Regulation / drug effects*
  • Gene Expression Regulation / genetics
  • Heart Ventricles / cytology
  • Heart Ventricles / drug effects
  • Hypertension / metabolism
  • Male
  • Organ Size / drug effects
  • Pyridines / pharmacology*
  • RNA, Messenger / metabolism
  • Rats
  • Rats, Inbred SHR
  • Rats, Inbred WKY
  • Renin-Angiotensin System / drug effects
  • Tetrazoles / pharmacology*
  • Transforming Growth Factor beta / biosynthesis
  • Transforming Growth Factor beta / genetics

Substances

  • Angiotensin Receptor Antagonists
  • Angiotensin-Converting Enzyme Inhibitors
  • Pyridines
  • RNA, Messenger
  • Tetrazoles
  • Transforming Growth Factor beta
  • forasartan
  • Angiotensin II
  • Collagen
  • Captopril
  • alacepril