Abstract
Agonist-stimulated hydrolysis of phosphatidylinositol 4,5-bisphosphate, which generates inositol 1,4,5-trisphosphate and sn-1,2-diacylglycerol, is thought to be one of the major mechanisms underlying pharmacomechanical coupling in airway smooth muscle. This article is a review of the currently available information on phosphoinositide and inositol 1,4,5-trisphosphate metabolism in this tissue and includes data on inositol 1,4,5-trisphosphate-induced Ca2+ release and the receptor mediating this effect. The final section outlines the potential mechanisms underlying physiological regulation of phosphoinositide metabolism by other second-messenger pathways operative in this tissue.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Calcium / metabolism
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Cyclic AMP / pharmacology
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Cyclic AMP-Dependent Protein Kinases / pharmacology
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Cyclic GMP / pharmacology
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Cyclic GMP-Dependent Protein Kinases / pharmacology
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Humans
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Hydrolysis
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Muscle, Smooth / drug effects
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Muscle, Smooth / metabolism*
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Phosphatidylinositols / agonists
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Phosphatidylinositols / metabolism*
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Protein Kinase C / pharmacology
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Respiratory System / drug effects
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Respiratory System / metabolism*
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Second Messenger Systems
Substances
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Phosphatidylinositols
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Cyclic AMP
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Cyclic AMP-Dependent Protein Kinases
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Cyclic GMP-Dependent Protein Kinases
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Protein Kinase C
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Cyclic GMP
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Calcium