Abstract
Evidence is presented for the formation of products in irradiated dinucleoside monophosphates in which both bases are damaged. The dinucleoside monophosphates d(GpT), d(GpC), d(TpG) and d(CpG) were X-irradiated in oxygenated aqueous solution. Product identification was by NMR spectroscopy. In products containing double base lesions, guanine is converted to 8-hydroxyguanine and the pyrimidine base is degraded to a formamido remnant.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Chromatography, High Pressure Liquid
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Deoxycytosine Nucleotides / chemistry
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Deoxycytosine Nucleotides / radiation effects*
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Deoxyguanosine / analogs & derivatives*
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Deoxyguanosine / chemistry
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Deoxyguanosine / radiation effects
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Dinucleoside Phosphates / chemistry
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Dinucleoside Phosphates / radiation effects*
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Free Radicals
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Guanosine / analogs & derivatives
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Magnetic Resonance Spectroscopy / methods
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Molecular Conformation
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Molecular Structure
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X-Rays
Substances
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Deoxycytosine Nucleotides
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Dinucleoside Phosphates
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Free Radicals
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Guanosine
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deoxycytidylyl-(3'-5')-deoxyguanosine
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8-hydroxyguanosine
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thymidylyl-(3',5')-2'-deoxyguanosine
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Deoxyguanosine