Metabotropic glutamate receptors contribute to the induction of long-term depression in the CA1 region of the hippocampus

Z I Bashir; D E Jane; D C Sunter; J C Watkins; G L Collingridge

doi:10.1016/0014-2999(93)91009-c

Metabotropic glutamate receptors contribute to the induction of long-term depression in the CA1 region of the hippocampus

Eur J Pharmacol. 1993 Aug 3;239(1-3):265-6. doi: 10.1016/0014-2999(93)91009-c.

Authors

Z I Bashir¹, D E Jane, D C Sunter, J C Watkins, G L Collingridge

Affiliation

¹ Department of Pharmacology, Medical School, University of Birmingham, Edgbaston, UK.

PMID: 8223907
DOI: 10.1016/0014-2999(93)91009-c

Abstract

Long-term depression of synaptic transmission was induced following the prior induction of long-term potentiation in the CA1 region of rat hippocampal slices. We show that the induction of this form of synaptic depression can be prevented by (+)-alpha-methyl-4-carboxyphenylglycine, a selective antagonist of metabotropic glutamate receptors.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Benzoates / pharmacology*
Electric Stimulation
Glycine / analogs & derivatives*
Glycine / pharmacology
Hippocampus / drug effects
Hippocampus / physiology*
In Vitro Techniques
Rats
Receptors, Metabotropic Glutamate / antagonists & inhibitors
Receptors, Metabotropic Glutamate / physiology*
Synaptic Transmission* / drug effects

Substances

Benzoates
Receptors, Metabotropic Glutamate
alpha-methyl-4-carboxyphenylglycine
Glycine