Abstract
The expression and synthesis regulation of the vesicle monoamine transporter was investigated in rat adrenal medulla. Previous studies established two genes for monoamine transporters by molecular techniques. In rat adrenal medulla, a differential expression of the corresponding mRNAs was found by in situ hybridization. The mRNA of monoamine transporter 2 was localized in chromaffin cells whereas monoamine transporter 1 mRNA occurred only in ganglion cells of the adrenal medulla. Insulin-induced hypoglycemia, a model for short neurogenic stimulation of the adrenal medulla, did not alter steady-state mRNA levels of both monoamine transporters.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adrenal Medulla / cytology*
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Adrenal Medulla / drug effects
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Adrenal Medulla / metabolism*
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Animals
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Chromaffin Granules / metabolism
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Glycoproteins / biosynthesis*
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Hypoglycemia / chemically induced
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Hypoglycemia / metabolism
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In Situ Hybridization
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Insulin / pharmacology
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Membrane Glycoproteins*
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Membrane Transport Proteins*
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Neuropeptides*
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RNA, Messenger / analysis
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RNA, Messenger / biosynthesis
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RNA, Messenger / metabolism*
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Rats
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Vesicular Biogenic Amine Transport Proteins
Substances
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Glycoproteins
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Insulin
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Membrane Glycoproteins
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Membrane Transport Proteins
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Neuropeptides
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RNA, Messenger
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Vesicular Biogenic Amine Transport Proteins