Endothelium-dependent relaxation to the B1 kinin receptor agonist des-Arg9-bradykinin in human coronary arteries

Br J Pharmacol. 1995 Dec;116(8):3083-5. doi: 10.1111/j.1476-5381.1995.tb15108.x.

Abstract

Des-Arg9-bradykinin (des-Arg9-BK) caused endothelium-dependent relaxations in human, isolated coronary arteries which upregulated with in vitro incubation time. Relaxations to des-Arg9-BK were inhibited by the B1 receptor antagonist, des-Arg9-[Leu3]-BK (pK(B), 6.14 +/- 0.11) but were unaffected by the B2 receptor antagonist, Hoe-140. Therefore, this is the first demonstration that human coronary arteries possess endothelial B1 receptors which mediate endothelium-dependent relaxation and appear to be synthesized de novo during the incubation period.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bradykinin / analogs & derivatives*
  • Bradykinin / pharmacology
  • Coronary Vessels / drug effects*
  • Coronary Vessels / metabolism
  • Endothelium, Vascular / drug effects*
  • Endothelium, Vascular / metabolism
  • Humans
  • In Vitro Techniques
  • Receptors, Bradykinin / agonists*
  • Receptors, Bradykinin / biosynthesis

Substances

  • Receptors, Bradykinin
  • bradykinin, des-Arg(9)-
  • icatibant
  • Bradykinin