Abstract
The HSP100/Clp proteins are a newly discovered family with a great diversity of functions, such as increased tolerance to high temperatures, promotion of proteolysis of specific cellular substrates and regulation of transcription. HSP100/Clp proteins are also synthesized in a variety of specific patterns and, in eukaryotes, are localized to different subcellular compartments. Recent data suggest that a common ability to disassemble higher-order protein structures and aggregates unifies the molecular functions of this diverse family.
MeSH terms
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ATPases Associated with Diverse Cellular Activities
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Adenosine Triphosphatases / metabolism
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Adenosine Triphosphatases / physiology
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Amino Acid Sequence
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Animals
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Bacteriophage mu / physiology
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Endopeptidase Clp
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Escherichia coli Proteins
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Heat-Shock Proteins / chemistry
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Heat-Shock Proteins / classification*
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Heat-Shock Proteins / physiology*
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Humans
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Mice
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Models, Biological
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Molecular Chaperones
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Molecular Sequence Data
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Protein Conformation
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Protozoan Proteins / physiology
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Saccharomyces cerevisiae Proteins*
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Serine Endopeptidases / physiology
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Stress, Physiological
Substances
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Escherichia coli Proteins
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Heat-Shock Proteins
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Molecular Chaperones
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Protozoan Proteins
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Saccharomyces cerevisiae Proteins
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HsP104 protein, S cerevisiae
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Serine Endopeptidases
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Endopeptidase Clp
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Adenosine Triphosphatases
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ClpB protein, Leishmania
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ClpX protein, E coli
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ATPases Associated with Diverse Cellular Activities
Associated data
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GENBANK/D17582
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GENBANK/D64000
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GENBANK/H10859
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GENBANK/L09547
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GENBANK/L16533
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GENBANK/L18867
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GENBANK/L34677
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GENBANK/L35272
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GENBANK/M29364
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GENBANK/M31045
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GENBANK/M32229
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GENBANK/M67479
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GENBANK/M76451
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GENBANK/M92325
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GENBANK/T18272
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GENBANK/U02604
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GENBANK/U09874
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GENBANK/U13949
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GENBANK/U16134
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GENBANK/U20646
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GENBANK/U39719
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GENBANK/U43536
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GENBANK/U46549
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GENBANK/X73140
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GENBANK/X75328
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GENBANK/X77160
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GENBANK/X95276
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GENBANK/Z25810
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GENBANK/Z29026
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GENBANK/Z38058