Abstract
Human hepatocyte nuclear factor 4 (hHNF-4) is a member of the nuclear hormone receptor superfamily and an important transcription factor and developmental regulator of liver-specific genes. Distinct hHNF-4 cDNAs corresponding to various HNF-4 isoforms have been recently characterised. Three cDNAs, hHNF-4A, B and C, are considered splice variants of a single hHNF-4 gene. We have mapped hHNF-4 to 20q12-q13.1 between PLCG1 and D20S17 by genetic linkage analysis, taking advantage of an adjacent PstI restriction fragment length polymorphism, (RFLP), and by fluorescence in situ hybridisation. hHFN-4 maps to chromosome 20 in a region syntenic with mouse chromosome 2 where the hnf-4 homologue has been assigned.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
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Chromosome Mapping*
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Chromosomes, Human, Pair 20*
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DNA-Binding Proteins*
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Genetic Linkage
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Genetic Markers
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Hepatocyte Nuclear Factor 4
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Humans
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In Situ Hybridization, Fluorescence
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Isoenzymes / genetics
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Phospholipase C gamma
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Phosphoproteins / genetics*
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Polymerase Chain Reaction
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Polymorphism, Restriction Fragment Length
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Transcription Factors / genetics*
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Type C Phospholipases / genetics
Substances
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Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
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DNA-Binding Proteins
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Genetic Markers
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Hepatocyte Nuclear Factor 4
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Isoenzymes
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MLX protein, human
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Phosphoproteins
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Tcfl4 protein, mouse
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Transcription Factors
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Type C Phospholipases
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Phospholipase C gamma