Comparison of adrenoceptor subtype expression in porcine and human bladder and prostate

Urol Res. 1997;25(3):199-206. doi: 10.1007/BF00941983.

Abstract

We have quantified and characterized alpha 1-, alpha 2- and beta-adrenoceptor subtypes in porcine bladder detrusor and bladder neck, human bladder detrusor, and porcine and human prostate. alpha 1-, alpha 2- and beta-adrenoceptor were identified in radioligand binding studies using [3H]prazosin, [3H]RX 821002 and [125I]iodocyanopindolol, respectively, as the radioligands. In porcine male and female detrusor and bladder neck and male prostate, adrenoceptors were detected in the order of abundance beta > alpha 2 >> alpha 1 (not detectable), with no major difference between the sexes or between detrusor and bladder neck. In human detrusor and prostate the order of abundance was beta > alpha 2 >> alpha 1 (not detectable) and beta >> alpha 1 > alpha 2, respectively. The alpha 2-adrenoceptors in all tissues were homogeneously of the alpha 2A-subtype as evidenced by competition binding studies with yohimbine, prazosin, ARC 239 and oxymetazoline. The beta-adrenoceptors represented a mixed population with a dominance of the beta 2-subtype in all tissues as demonstrated by competition binding with ICI 118,551 and CGP 20,712A. We conclude that pigs may be a suitable model for studies of detrusor function with respect to adrenoceptor expression. They may be less suitable for studies of bladder neck or prostate function.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenergic alpha-1 Receptor Agonists
  • Adrenergic alpha-1 Receptor Antagonists
  • Adrenergic alpha-2 Receptor Agonists
  • Adrenergic alpha-2 Receptor Antagonists
  • Adrenergic alpha-Agonists / pharmacology
  • Adrenergic alpha-Antagonists / pharmacology*
  • Adrenergic beta-Antagonists / pharmacology
  • Animals
  • Binding, Competitive / physiology
  • Female
  • Humans
  • Imidazoles / pharmacology
  • Isoquinolines / pharmacology
  • Male
  • Oxymetazoline / pharmacology
  • Piperazines / pharmacology
  • Prazosin / pharmacology
  • Propanolamines / pharmacology
  • Prostate / chemistry*
  • Radioligand Assay
  • Receptors, Adrenergic / analysis*
  • Receptors, Adrenergic, alpha-1 / analysis
  • Receptors, Adrenergic, alpha-2 / analysis
  • Receptors, Adrenergic, beta / analysis
  • Swine
  • Urinary Bladder / chemistry*
  • Yohimbine / pharmacology

Substances

  • Adrenergic alpha-1 Receptor Agonists
  • Adrenergic alpha-1 Receptor Antagonists
  • Adrenergic alpha-2 Receptor Agonists
  • Adrenergic alpha-2 Receptor Antagonists
  • Adrenergic alpha-Agonists
  • Adrenergic alpha-Antagonists
  • Adrenergic beta-Antagonists
  • Imidazoles
  • Isoquinolines
  • Piperazines
  • Propanolamines
  • Receptors, Adrenergic
  • Receptors, Adrenergic, alpha-1
  • Receptors, Adrenergic, alpha-2
  • Receptors, Adrenergic, beta
  • Yohimbine
  • ICI 118551
  • Oxymetazoline
  • CGP 20712A
  • AR-C239
  • Prazosin