Receptor localization in the mammalian dorsal horn and primary afferent neurons

Brain Res Brain Res Rev. 1997 Jun;24(1):28-66. doi: 10.1016/s0165-0173(97)00010-6.

Abstract

The dorsal horn of the spinal cord is a primary receiving area for somatosensory input and contains high concentrations of a large variety of receptors. These receptors tend to congregate in lamina II, which is a major receiving center for fine, presumably nociceptive, somatosensory input. There are rapid reorganizations of many of these receptors in response to various stimuli or pathological situations. These receptor localizations in the normal and their changes after various pertubations modify present concepts about the wiring diagram of the nervous system. Accordingly, the present work reviews the receptor localizations and relates them to classic organizational patterns in the mammalian dorsal horn.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Humans
  • Neurons, Afferent / metabolism*
  • Neurons, Afferent / ultrastructure
  • Receptors, Cell Surface / physiology*
  • Spinal Cord / cytology
  • Spinal Cord / metabolism*
  • Spinal Cord / ultrastructure

Substances

  • Receptors, Cell Surface