Abstract
The crystal structure of human replication and transcription cofactor PC4CTD reveals a dimer with two single-stranded (ss)DNA binding channels running in opposite directions to each other. This arrangement suggests a role in establishment or maintenance of melted DNA at promoters or origins of replication.
Publication types
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Binding Sites
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Crystallography, X-Ray
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DNA, Single-Stranded / metabolism*
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Dimerization
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Humans
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Immediate-Early Proteins
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Membrane Proteins
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Models, Molecular
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Molecular Sequence Data
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Repressor Proteins*
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Trans-Activators / chemistry*
Substances
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DNA, Single-Stranded
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IFRD2 protein, human
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Immediate-Early Proteins
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Membrane Proteins
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Repressor Proteins
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Trans-Activators