H+ pump-dependent changes in membrane voltage are an early mechanism necessary and sufficient to induce Xenopus tail regeneration

DS Adams, A Masi, M Levin - 2007 - journals.biologists.com
In many systems, ion flows and long-term endogenous voltage gradients regulate patterning
events, but molecular details remain mysterious. To establish a mechanistic link between …

Targeting ion channels in cancer: a novel frontier in antineoplastic therapy

…, O Crociani, E Lastraioli, A Masi… - Current medicinal …, 2009 - ingentaconnect.com
Targeted therapy is considerably changing the treatment and prognosis of cancer.
Progressive understanding of the molecular mechanisms that regulate the establishment and …

Induction of vertebrate regeneration by a transient sodium current

AS Tseng, WS Beane, JM Lemire, A Masi… - Journal of …, 2010 - Soc Neuroscience
Amphibians such as frogs can restore lost organs during development, including the lens
and tail. To design biomedical therapies for organ repair, it is necessary to develop a detailed …

The hyperpolarization-activated cyclic nucleotide–gated channels: from biophysics to pharmacology of a unique family of ion channels

L Sartiani, G Mannaioni, A Masi, MN Romanelli… - Pharmacological …, 2017 - ASPET
Hyperpolarization-activated, cyclic nucleotide–gated (HCN) channels are important members
of the voltage-gated pore loop channels family. They show unique features: they open at …

Cardiac and neuronal HCN channelopathies

I Rivolta, A Binda, A Masi, JC DiFrancesco - Pflügers Archiv-European …, 2020 - Springer
Hyperpolarization-activated cyclic nucleotide–gated (HCN) channels are expressed as four
different isoforms (HCN1-4) in the heart and in the central and peripheral nervous systems. …

[HTML][HTML] Reward-related behavioral, neurochemical and electrophysiological changes in a rat model of autism based on prenatal exposure to valproic acid

…, M Petrella, G Mannaioni, A Masi… - Frontiers in cellular …, 2019 - frontiersin.org
Prenatal exposure to the antiepileptic drug valproic acid (VPA) induces autism spectrum
disorder (ASD) in humans and autistic-like behaviors in rodents, which makes it a good model …

[HTML][HTML] GPR35 Activation Reduces Ca2+ Transients and Contributes to the Kynurenic Acid-Dependent Reduction of Synaptic Activity at CA3-CA1 Synapses

R Berlinguer-Palmini, A Masi, R Narducci, L Cavone… - PloS one, 2013 - journals.plos.org
Limited information is available on the brain expression and role of GPR35, a Gi/o coupled
receptor activated by kynurenic acid (KYNA). In mouse cultured astrocytes, we detected …

HCN channels modulators: the need for selectivity

M Novella Romanelli, L Sartiani, A Masi… - Current Topics in …, 2016 - ingentaconnect.com
Hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels, the molecular correlate
of the hyperpolarization-activated current (If/Ih), are membrane proteins which play an …

Kynurenic acid and zaprinast induce analgesia by modulating HCN channels through GPR35 activation

F Resta, A Masi, M Sili, A Laurino, F Moroni… - …, 2016 - Elsevier
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels have a key role in the
control of cellular excitability. HCN2, a subgroup of the HCN family channels, are heavily …

The conformational state of hERG1 channels determines integrin association, downstream signaling, and cancer progression

…, S Manoli, MF Brizzi, D Ricci, M Rinaldi, A Masi… - Science …, 2017 - science.org
Ion channels regulate cell proliferation, differentiation, and migration in normal and neoplastic
cells through cell-cell and cell–extracellular matrix (ECM) transmembrane receptors called …