Background Accurate population-based data are needed on the incidence of esophageal
adenocarcinoma and high-grade dysplasia among patients with Barrett's esophagus. Methods …

Chronic pancreatitis is defined as a pathological fibro-inflammatory syndrome of the pancreas
in individuals with genetic, environmental and/or other risk factors who develop persistent …

Treatment of pain is one of the major challenges in clinical medicine. However, it is often
difficult to evaluate the effect of a treatment, as the many symptoms of the underlying diseases …

BACKGROUND & AIMS: Pain is a disabling symptom for patients with chronic pancreatitis (CP)
and difficult to treat. Evidence from basic science and human studies indicates that pain …

The present human study aimed at investigating the effect of subcutaneous administration
of Botulinum toxin type A (BoNT/A) on capsaicin-induced trigeminal pain, neurogenic …

Opioids are the most commonly prescribed medications to treat severe pain in the Western
world. It has been estimated that up to 90% of American patients presenting to specialized …

Pain models in animals have shown low predictivity for analgesic efficacy in humans, and
clinical studies are often very confounded, blurring the evaluation. Human experimental pain …

Objective To formulate timely evidence-based guidelines for the management of opioid-induced
bowel dysfunction. Setting Constipation is a major untoward effect of opioids. Increasing …

Pain mechanisms in patients with chronic pancreatitis are incompletely understood and
probably multifactorial. Recently, evidence from experimental human pain research has …

Chronic pancreatitis (CP) is an inflammatory disease of the pancreas characterized by
progressive fibrotic destruction of the pancreatic secretory parenchyma. Despite the heterogeneity …