User profiles for Craig W. Lindsley

Craig Lindsley

Vanderbilt University
Verified email at vanderbilt.edu
Cited by 33345

Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors

CW Lindsley, Z Zhao, WH Leister, RG Robinson… - Bioorganic & medicinal …, 2005 - Elsevier
This letter describes the development of two series of potent and selective allosteric Akt
kinase inhibitors that display an unprecedented level of selectivity for either Akt1, Akt2 or both …

Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

…, A Christopoulos, CW Lindsley - Nature reviews Drug …, 2009 - nature.com
Despite G-protein-coupled receptors (GPCRs) being among the most fruitful targets for
marketed drugs, intense discovery efforts for several GPCR subtypes have failed to deliver …

The Akt/PKB pathway: molecular target for cancer drug discovery

JQ Cheng, CW Lindsley, GZ Cheng, H Yang… - Oncogene, 2005 - nature.com
The serine/threonine kinase Akt/PKB pathway presents an exciting new target for molecular
therapeutics, as it functions as a cardinal nodal point for transducing extracellular (growth …

Efficient synthesis of imidazoles from aldehydes and 1, 2-diketones using microwave irradiation

…, WH Leister, Y Wang, Z Zhao, CW Lindsley - Organic …, 2004 - ACS Publications
A simple, high-yielding synthesis of 2,4,5-trisubstituted imidazoles from 1,2-diketones and
aldehydes in the presence of NH 4 OAc is described. Under microwave irradiation, alkyl-, aryl-…

In Vivo Structure−Activity Relationship Study of Dorsomorphin Analogues Identifies Selective VEGF and BMP Inhibitors

…, PR Gentry, CR Hopkins, CW Lindsley… - ACS chemical …, 2010 - ACS Publications
The therapeutic potential of small molecule signaling inhibitors is often limited by off-target
effects. Recently, in a screen for compounds that perturb the zebrafish embryonic …

Activation of metabotropic glutamate receptors as a novel approach for the treatment of schizophrenia

PJ Conn, CW Lindsley, CK Jones - Trends in pharmacological sciences, 2009 - cell.com
In recent years, the metabotropic glutamate (mGlu) receptors have emerged as potential
new drug targets for treatment of a range of CNS disorders. Some of the most compelling …

Phospholipase D: enzymology, functionality, and chemical modulation

PE Selvy, RR Lavieri, CW Lindsley, HA Brown - Chemical reviews, 2011 - ACS Publications
Phosphatidic acid (PA) is a critical phospholipid constituent in eukaryotic cell membranes,
which accounts for 1Ą4% of the total lipid. 1 This lipophilic glycerophospholipid has a …

A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models

…, TB Chen, DD Wisnoski, CW Lindsley… - … of Pharmacology and …, 2005 - ASPET
We found that 3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide (CDPPB) is a potent
and selective positive allosteric modulator of the metabotropic glutamate receptor subtype 5 (…

Selective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiation

…, L Veng, CW Lindsley, W Shipe… - Proceedings of the …, 2009 - National Acad Sciences
The forebrain cholinergic system promotes higher brain function in part by signaling through
the M 1 muscarinic acetylcholine receptor (mAChR). During Alzheimer's disease (AD), …

General microwave-assisted protocols for the expedient synthesis of quinoxalines and heterocyclic pyrazines

…, SE Wolkenberg, WH Leister, Y Wang, CW Lindsley - Tetrahedron …, 2004 - Elsevier
Functionalized quinoxalines and heterocyclic pyrazines are expediently prepared in excellent
yields (69–99%) from common 1,2-diketone intermediates under microwave irradiation. In …