Ionized calcium (Ca 2÷) is the most common signal transduction element in cells ranging from
bacteria to specialized neurons. Unlike many other second-messenger mo! ecules, Ca 2÷ …

Calcium ions (Ca 2+ ) impact nearly every aspect of cellular life. This review examines the
principles of Ca 2+ signaling, from changes in protein conformations driven by Ca 2+ to the …

TRP channels are the vanguard of our sensory systems, responding to temperature, touch,
pain, osmolarity, pheromones, taste and other stimuli. But their role is much broader than …

Subunits ofguanine nucleotide regulatory proteins purified from bovine cerebral cortex were
used to perfuse the intracellular surface of excised patches of chick embryonic atrial cells. …

▪ Abstract The aim of this review is to provide a basic framework for understanding the function
of mammalian transient receptor potential (TRP) channels, particularly as they have been …

During intracellular Ca 2+ signalling mitochondria accumulate significant amounts of Ca 2+
from the cytosol 1 , 2 . Mitochondrial Ca 2+ uptake controls the rate of energy production 1 , 3 …

… & Clapham, DE TRPC1 and TRPC5 form a novel cation channel in mammalian brain. Neuron
29, 645–655 (2001).Showed that TRPC channels formed heteromers in mammalian brain, …

… channels found in heart [I KACh , GIRK1/CIR (92)], brain [GIRK1/GIRK2 (93)] and very likely
for the G protein inhibition of the N and P/Q type calcium channels [reviewed in Clapham (94)…

Heart rate is slowed in part by acetylcholine-dependent activation of a cardiac potassium (K
+ ) channel, I KACh . Activated muscarinic receptors stimulate l KAch via the G-protein βγ-…

Calcium and cyclic nucleotides have crucial roles in mammalian fertilization, but the molecules
comprising the Ca 2+ -permeation pathway in sperm motility are poorly understood. Here …