Restoration of reaching and grasping movements through brain-controlled muscle stimulation in a person with tetraplegia: a proof-of-concept demonstration
Background People with chronic tetraplegia, due to high-cervical spinal cord injury, can
regain limb movements through coordinated electrical stimulation of peripheral muscles and …
regain limb movements through coordinated electrical stimulation of peripheral muscles and …
[PDF][PDF] The global burden of metabolic disease: Data from 2000 to 2019
Global estimates of prevalence, deaths, and disability-adjusted life years (DALYs) from the
Global Burden of Diseases, Injuries, and Risk Factors Study 2019 were examined for …
Global Burden of Diseases, Injuries, and Risk Factors Study 2019 were examined for …
The institutionalization of political power in Africa
On 16 May 2006, after months of intense and divisive national debate, the Senate of Nigeria
rejected a bill which would have changed that country's constitution to permit President …
rejected a bill which would have changed that country's constitution to permit President …
Matrix metalloproteinases: from molecular mechanisms to physiology, pathophysiology, and pharmacology
The first matrix metalloproteinase (MMP) was discovered in 1962 from the tail of a tadpole
by its ability to degrade collagen. As their name suggests, matrix metalloproteinases are …
by its ability to degrade collagen. As their name suggests, matrix metalloproteinases are …
Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression
…, JL Stein, M Montecino, A Javed, SK Zaidi, DW Young… - Oncogene, 2004 - nature.com
We present an overview of Runx involvement in regulatory mechanisms that are requisite
for fidelity of bone cell growth and differentiation, as well as for skeletal homeostasis and the …
for fidelity of bone cell growth and differentiation, as well as for skeletal homeostasis and the …
Networks and hubs for the transcriptional control of osteoblastogenesis
We present an overview of the concepts of tissue-specific transcriptional control mechanisms
essential for development of the bone cell phenotype. BMP2 induced transcription factors …
essential for development of the bone cell phenotype. BMP2 induced transcription factors …
[HTML][HTML] Integrating high-content screening and ligand-target prediction to identify mechanism of action
DW Young, A Bender, J Hoyt, E McWhinnie… - Nature chemical …, 2008 - nature.com
High-content screening is transforming drug discovery by enabling simultaneous measurement
of multiple features of cellular phenotype that are relevant to therapeutic and toxic …
of multiple features of cellular phenotype that are relevant to therapeutic and toxic …
[PDF][PDF] A comprehensive review of interventions in the NOD mouse and implications for translation
LKM Shoda, DL Young, S Ramanujan, CC Whiting… - Immunity, 2005 - cell.com
Type 1 diabetes (T1D) animal models such as the nonobese diabetic (NOD) mouse have
improved our understanding of disease pathophysiology, but many candidate therapeutics …
improved our understanding of disease pathophysiology, but many candidate therapeutics …
Multi-parameter phenotypic profiling: using cellular effects to characterize small-molecule compounds
Y Feng, TJ Mitchison, A Bender, DW Young… - Nature Reviews Drug …, 2009 - nature.com
Multi-parameter phenotypic profiling of small molecules provides important insights into their
mechanisms of action, as well as a systems level understanding of biological pathways and …
mechanisms of action, as well as a systems level understanding of biological pathways and …
Jet‐based methods to print living cells
Cell printing has been popularized over the past few years as a revolutionary advance in
tissue engineering has potentially enabled heterogeneous 3‐D scaffolds to be built cell‐by‐cell…
tissue engineering has potentially enabled heterogeneous 3‐D scaffolds to be built cell‐by‐cell…