User profiles for David P. Siderovski

David P. Siderovski

Chair of HSC Dept. of Pharmacology & Neuroscience
Verified email at unthsc.edu
Cited by 26300

Molecular characterization of mitochondrial apoptosis-inducing factor

…, DR Goodlett, R Aebersold, DP Siderovski… - Nature, 1999 - nature.com
Mitochondria play a key part in the regulation of apoptosis (cell death) 1 , 2 . Their
intermembrane space contains several proteins that are liberated through the outer membrane in …

[HTML][HTML] Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

…, T Sasaki, J Ruland, JM Penninger, DP Siderovski… - Cell, 1998 - cell.com
PTEN is a tumor suppressor with sequence homology to protein tyrosine phosphatases and
the cytoskeletal protein tensin. mPTEN-mutant mouse embryos display regions of increased …

[HTML][HTML] The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits

DP Siderovski, FS Willard - International journal of biological …, 2005 - ncbi.nlm.nih.gov
The heterotrimeric G-protein alpha subunit has long been considered a bimodal, GTP-hydrolyzing
switch controlling the duration of signal transduction by seven-transmembrane …

Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure

…, KM Kaltenbronn, KJ Blumer, DP Siderovski… - Nature medicine, 2003 - nature.com
Nitric oxide (NO) inhibits vascular contraction by activating cGMP-dependent protein kinase I-α
(PKGI-α), which causes dephosphorylation of myosin light chain (MLC) and vascular …

Regulators of G-protein signalling as new central nervous system drug targets

RR Neubig, DP Siderovski - Nature Reviews Drug Discovery, 2002 - nature.com
G-protein-coupled receptors (GPCRs) are major targets for drug discovery. The regulator of
G-protein signalling (RGS)-protein family has important roles in GPCR signal transduction. …

Tiam1 mediates Ras activation of Rac by a PI (3) K-independent mechanism

…, QT Lambert, GW Reuther, A Malliri, DP Siderovski… - Nature cell …, 2002 - nature.com
Rac is a member of the Ras superfamily of GTPases and functions as a GDP/GTP-regulated
switch 1 . Formation of active Rac-GTP is stimulated by Dbl family guanine nucleotide …

A seven-transmembrane RGS protein that modulates plant cell proliferation

…, J Liang, SA Chasse, AM Jones, DP Siderovski - Science, 2003 - science.org
G protein–coupled receptors (GPCRs) at the cell surface activate heterotrimeric G proteins
by inducing the G protein alpha (Gα) subunit to exchange guanosine diphosphate for …

Translation of Polarity Cues into Asymmetric Spindle Positioning in Caenorhabditis elegans Embryos

…, RJ Kimple, FS Willard, DP Siderovski, P Gönczy - Science, 2003 - science.org
Asymmetric divisions are crucial for generating cell diversity; they rely on coupling between
polarity cues and spindle positioning, but how this coupling is achieved is poorly understood. …

Regulation of T cell activation, anxiety, and male aggression by RGS2

…, JC Roder, CA Barnes, DP Siderovski… - Proceedings of the …, 2000 - National Acad Sciences
Regulators of G protein signaling (RGS) proteins accelerate the GTPase activity of Gα
protein subunits in vitro, negatively regulating G protein-coupled receptor signaling. The …

Regulators of G-protein signaling and their Gα substrates: promises and challenges in their use as drug discovery targets

…, DE Bosch, PM Gigučre, DP Siderovski - Pharmacological reviews, 2011 - ASPET
Because G-protein coupled receptors (GPCRs) continue to represent excellent targets for
the discovery and development of small-molecule therapeutics, it is posited that additional …