ATP-sensitive P2X 7 receptors are localized on cells of immunological origin including glial
cells in the central nervous system. Activation of P2X 7 receptors leads to rapid changes in …

Background and purpose: Acute activation of P2X7 receptors rapidly opens a non‐selective
cation channel. Sustained P2X7 receptor activation leads to the formation of cytolytic pores, …

1-Benzyl-5-aryltetrazoles were discovered to be novel antagonists for the P2X 7 receptor.
Structure−activity relationship (SAR) studies were conducted around both the benzyl and …

Recent evidence indicating the therapeutic potential of cholinergic channel modulators for
the treatment of central nervous system (CNS) disorders as well as the diversity of brain …

[2, 4]-Dimethoxybenzylidene anabaseine dihydrochloride (GTS-21), a compound that interacts
with rat neuronal nicotinic acetylcholine receptors (nAChRs), was evaluated using human …

Multiple P2 receptor-mediated mechanisms exist by which ATP can alter nociceptive
sensitivity following tissue injury. Evidence from a variety of experimental strategies, including …

10.7554/eLife.42940.001 The integrated stress response (ISR) attenuates the rate of protein
synthesis while inducing expression of stress proteins in cells. Various insults activate …

Progress in the fields of neuroscience and molecular biology has identified the forebrain
cholinergic system as being important in many higher order brain functions. Further analysis of …

(-)-Nicotine, the prototypical agonist for neuronal nicotinic acetylcholine receptors (nAChR)
has been shown to bind with high affinity to the rodent and avian alpha 4 beta 2 nAChR …

The pro-inflammatory cytokine interleukin-1β (IL-1β) has been implicated in both inflammatory
processes and nociceptive neurotransmission. Activation of P2X7 receptors is the …