A-740003 [N-(1-{[(cyanoimino)(5-quinolinylamino) methyl] amino}-2, 2-dimethylpropyl)-2-(3, 4-dimethoxyphenyl) acetamide], a novel and selective P2X7 receptor …
P Honore, D Donnelly-Roberts, MT Namovic… - Journal of pharmacology …, 2006 - ASPET
ATP-sensitive P2X 7 receptors are localized on cells of immunological origin including glial
cells in the central nervous system. Activation of P2X 7 receptors leads to rapid changes in …
cells in the central nervous system. Activation of P2X 7 receptors leads to rapid changes in …
Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors
DL Donnelly‐Roberts, MT Namovic… - British journal of …, 2009 - Wiley Online Library
Background and purpose: Acute activation of P2X7 receptors rapidly opens a non‐selective
cation channel. Sustained P2X7 receptor activation leads to the formation of cytolytic pores, …
cation channel. Sustained P2X7 receptor activation leads to the formation of cytolytic pores, …
Structure−Activity Relationship Studies on a Series of Novel, Substituted 1-Benzyl-5-phenyltetrazole P2X7 Antagonists
…, MT Namovic, DL Donnelly-Roberts… - Journal of medicinal …, 2006 - ACS Publications
1-Benzyl-5-aryltetrazoles were discovered to be novel antagonists for the P2X 7 receptor.
Structure−activity relationship (SAR) studies were conducted around both the benzyl and …
Structure−activity relationship (SAR) studies were conducted around both the benzyl and …
Novel 3-pyridyl ethers with subnanomolar affinity for central neuronal nicotinic acetylcholine receptors
…, YC Martin, DL Donnelly-Roberts… - Journal of medicinal …, 1996 - ACS Publications
Recent evidence indicating the therapeutic potential of cholinergic channel modulators for
the treatment of central nervous system (CNS) disorders as well as the diversity of brain …
the treatment of central nervous system (CNS) disorders as well as the diversity of brain …
Functional characterization of the novel neuronal nicotinic acetylcholine receptor ligand GTS-21 in vitro and in vivo
…, MW Decker, D DONNELLY–ROBERTS… - Pharmacology …, 1997 - Elsevier
[2, 4]-Dimethoxybenzylidene anabaseine dihydrochloride (GTS-21), a compound that interacts
with rat neuronal nicotinic acetylcholine receptors (nAChRs), was evaluated using human …
with rat neuronal nicotinic acetylcholine receptors (nAChRs), was evaluated using human …
Painful purinergic receptors
D Donnelly-Roberts, S McGaraughty, CC Shieh… - … of Pharmacology and …, 2008 - ASPET
Multiple P2 receptor-mediated mechanisms exist by which ATP can alter nociceptive
sensitivity following tissue injury. Evidence from a variety of experimental strategies, including …
sensitivity following tissue injury. Evidence from a variety of experimental strategies, including …
eIF2B activator prevents neurological defects caused by a chronic integrated stress response
…, AL Nikkel, HM Robb, DL Donnelly-Roberts… - Elife, 2019 - elifesciences.org
10.7554/eLife.42940.001 The integrated stress response (ISR) attenuates the rate of protein
synthesis while inducing expression of stress proteins in cells. Various insults activate …
synthesis while inducing expression of stress proteins in cells. Various insults activate …
Therapeutic potential of α7 nicotinic acetylcholine receptors
…, D Flood, F Marger, D Donnelly-Roberts - Pharmacological …, 2015 - ASPET
Progress in the fields of neuroscience and molecular biology has identified the forebrain
cholinergic system as being important in many higher order brain functions. Further analysis of …
cholinergic system as being important in many higher order brain functions. Further analysis of …
Stable expression, pharmacologic properties and regulation of the human neuronal nicotinic acetylcholine alpha 4 beta 2 receptor.
…, M Piattoni-Kaplan, D Donnelly-Roberts… - … of Pharmacology and …, 1996 - ASPET
(-)-Nicotine, the prototypical agonist for neuronal nicotinic acetylcholine receptors (nAChR)
has been shown to bind with high affinity to the rodent and avian alpha 4 beta 2 nAChR …
has been shown to bind with high affinity to the rodent and avian alpha 4 beta 2 nAChR …
The antihyperalgesic activity of a selective P2X7 receptor antagonist, A-839977, is lost in IL-1αβ knockout mice
P Honore, D Donnelly-Roberts, M Namovic… - Behavioural brain …, 2009 - Elsevier
The pro-inflammatory cytokine interleukin-1β (IL-1β) has been implicated in both inflammatory
processes and nociceptive neurotransmission. Activation of P2X7 receptors is the …
processes and nociceptive neurotransmission. Activation of P2X7 receptors is the …