Ceramides increase during obesity and promote insulin resistance. Ceramides vary in acyl-chain
lengths from C 14:0 to C 30:0 and are synthesized by six ceramide synthase enzymes (…

The contribution of altered post-transcriptional gene silencing to the development of insulin
resistance and type 2 diabetes mellitus so far remains elusive. Here, we demonstrate that …

Natriuretic peptides (NPs) are a group of peptide-hormones mainly secreted from the heart,
signaling via c-GMP coupled receptors. NP are well known for their renal and cardiovascular …

The solute carrier (SLC) superfamily comprises more than 400 transport proteins mediating
the influx and efflux of substances such as ions, nucleotides, and sugars across biological …

Reduced expression of the Indy (“I am Not Dead, Yet”) gene in lower organisms promotes
longevity in a manner akin to caloric restriction. Deletion of the mammalian homolog of Indy (…

In addition to tissues such as liver, the plasma membrane sodium-dependent citrate transporter,
NaCT (SLC13A5), is highly expressed in brain neurons, but its function is not understood…

The regulation of metabolic processes by the Indy (I′m Not Dead Yet) (SLC13A5/NaCT)
gene was revealed through studies in Drosophila melanogaster and Caenorhabditis elegans. …

Chronic nutrient excess leads to metabolic disorders and insulin resistance. Activation of
stress-responsive pathways via Nrf2 activation contributes to energy metabolism regulation. …

Reduced expression of the INDY (I'm not dead yet) tricarboxylate carrier increased the life
span in different species by mechanisms akin to caloric restriction. Mammalian INDY homolog …

Pancreatic β cells store insulin within secretory granules which undergo exocytosis upon
elevation of blood glucose levels. Crinophagy and autophagy are instead responsible to …