Pharmacokinetic-pharmacodynamic (PKPD) modeling and simulation has evolved as an
important tool for rational drug development and drug use, where developed models …

Therapeutic drug monitoring (TDM) and model‐informed precision dosing (MIPD) have
evolved as important tools to inform rational dosing of antibiotics in individual patients with …

Carbapenems are vital antibiotics, but their efficacy is increasingly compromised by metallo-β-lactamases
(MBLs). Here we report the discovery and optimization of potent broad-…

Critically ill patients with severe infections are at high risk of suboptimal antimicrobial dosing.
The pharmacokinetics (PK) and pharmacodynamics (PD) of antimicrobials in these patients …

A pharmacokinetic-pharmacodynamic (PKPD) model that characterizes the full time course
of in vitro time-kill curve experiments of antibacterial drugs was here evaluated in its capacity …

Dosing of antibacterial agents is generally based on point estimates of the effect, even though
bacteria exposed to antibiotics show complex kinetic behaviors. The use of the whole time …

Background The addition of oral entacapone to levodopa‐carbidopa intestinal gel treatment
leads to less conversion of levodopa to 3‐O‐methyldopa, thereby increasing levodopa …

Gentamicin is commonly used in the management of neonatal infections. Development of
adaptive resistance is typical for aminoglycosides and reduces the antibacterial effect. There is…

Purpose Recently, a covariate model characterizing developmental changes in clearance of
amikacin in neonates has been developed using birth bodyweight and postnatal age. The …

Antibiotic resistance presents an incessant threat to our drug armamentarium that
necessitates novel approaches to therapy. Over the past several decades, investigation of …