Apoptosis induced in neuronal cells by oxidative stress: role played by caspases and intracellular calcium ions

…, R Sirabella, A Secondo, L Sibaud, GF Di Renzo - Toxicology letters, 2003 - Elsevier
Reactive oxygen species (ROS) have been implicated in the pathophysiology of many
neurologic disorders and brain dysfunction. In the same pathological settings evidence has been …

Pharmacology of brain Na+/Ca2+ exchanger: from molecular biology to therapeutic perspectives

L Annunziato, G Pignataro, GF Di Renzo - Pharmacological reviews, 2004 - ASPET
In the last two decades, there has been a growing interest in unraveling the role that the Na
+ /Ca 2+ exchanger (NCX) plays in the function and regulation of several cellular activities. …

ncx1, ncx2, and ncx3 Gene Product Expression and Function in Neuronal Anoxia and Brain Ischemia

…, A Scorziello, M Cataldi, GF Di Renzo - Annals of the New …, 2007 - Wiley Online Library
Over the last few years, although extensive studies have focused on the relevant function
played by the sodium–calcium exchanger (NCX) during focal ischemia, a thorough …

Up-regulation and increased activity of KV3. 4 channels and their accessory subunit MinK-related peptide 2 induced by amyloid peptide are involved in apoptotic …

…, R Sirabella, M Taglialatela, GF Di Renzo… - Molecular …, 2007 - ASPET
The aim of the present study was to investigate whether K V 3.4 channel subunits are involved
in neuronal death induced by neurotoxic β-amyloid peptides (Aβ). In particular, to test this …

Na+–Ca2+ exchanger (NCX3) knock-out mice display an impairment in hippocampal long-term potentiation and spatial learning and memory

…, S Sokolow, A Herchuelz, GF Di Renzo… - Journal of …, 2011 - Soc Neuroscience
Long-term potentiation (LTP) depends on the coordinated regulation of an ensemble of proteins
related to Ca 2+ homeostasis, including Ca 2+ transporters. One of the major players in …

[HTML][HTML] Endoplasmic reticulum refilling and mitochondrial calcium extrusion promoted in neurons by NCX1 and NCX3 in ischemic preconditioning are determinant for …

…, V Valsecchi, C Savoia, GF Di Renzo… - Cell Death & …, 2014 - nature.com
Ischemic preconditioning (IPC), an important endogenous adaptive mechanism of the CNS,
renders the brain more tolerant to lethal cerebral ischemia. The molecular mechanisms …

HIF‐1α reveals a binding activity to the promoter of iNOS gene after permanent middle cerebral artery occlusion

…, C Irace, A Scorziello, GF Di Renzo… - Journal of …, 2004 - Wiley Online Library
Hypoxia inducible factor (HIF‐1)‐1α is a specific, oxygen‐sensitive protein that regulates
the activity of HIF‐1, a transcriptional factor that increases after cerebral ischemia and may …

Prolactin secretion in man: a useful tool to evaluate the activity of drugs on central 5‐hydroxytryptaminergic neurones. Studies with fenfluramine.

…, U Aguglia, F Scopacasa, GF Direnzo… - British journal of …, 1983 - Wiley Online Library
Acute oral administration of various doses of fenfluramine, a 5‐HT releaser, induced a dose‐related
increase of PRL secretion in nine healthy volunteers. Fenfluramine reached the …

[HTML][HTML] Ischemic tolerance modulates TRAIL expression and its receptors and generates a neuroprotected phenotype

…, A Vinciguerra, O Cuomo, GF Di Renzo… - Cell Death & …, 2014 - nature.com
TNF-related apoptosis inducing ligand (TRAIL), a member of the TNF superfamily released
by microglia, appears to be involved in the induction of apoptosis following focal brain …

NO‐induced neuroprotection in ischemic preconditioning stimulates mitochondrial Mn‐SOD activity and expression via RAS/ERK1/2 pathway

…, LMT Canzoniero, GFD Renzo… - Journal of …, 2007 - Wiley Online Library
To identify the transductional mechanisms responsible for the neuroprotective effect of nitric
oxide (NO) during ischemic preconditioning (IPC), we investigated the effects of this …