Apoptosis induced in neuronal cells by oxidative stress: role played by caspases and intracellular calcium ions
…, R Sirabella, A Secondo, L Sibaud, GF Di Renzo - Toxicology letters, 2003 - Elsevier
Reactive oxygen species (ROS) have been implicated in the pathophysiology of many
neurologic disorders and brain dysfunction. In the same pathological settings evidence has been …
neurologic disorders and brain dysfunction. In the same pathological settings evidence has been …
Pharmacology of brain Na+/Ca2+ exchanger: from molecular biology to therapeutic perspectives
In the last two decades, there has been a growing interest in unraveling the role that the Na
+ /Ca 2+ exchanger (NCX) plays in the function and regulation of several cellular activities. …
+ /Ca 2+ exchanger (NCX) plays in the function and regulation of several cellular activities. …
ncx1, ncx2, and ncx3 Gene Product Expression and Function in Neuronal Anoxia and Brain Ischemia
Over the last few years, although extensive studies have focused on the relevant function
played by the sodium–calcium exchanger (NCX) during focal ischemia, a thorough …
played by the sodium–calcium exchanger (NCX) during focal ischemia, a thorough …
Up-regulation and increased activity of KV3. 4 channels and their accessory subunit MinK-related peptide 2 induced by amyloid peptide are involved in apoptotic …
…, R Sirabella, M Taglialatela, GF Di Renzo… - Molecular …, 2007 - ASPET
The aim of the present study was to investigate whether K V 3.4 channel subunits are involved
in neuronal death induced by neurotoxic β-amyloid peptides (Aβ). In particular, to test this …
in neuronal death induced by neurotoxic β-amyloid peptides (Aβ). In particular, to test this …
Na+–Ca2+ exchanger (NCX3) knock-out mice display an impairment in hippocampal long-term potentiation and spatial learning and memory
…, S Sokolow, A Herchuelz, GF Di Renzo… - Journal of …, 2011 - Soc Neuroscience
Long-term potentiation (LTP) depends on the coordinated regulation of an ensemble of proteins
related to Ca 2+ homeostasis, including Ca 2+ transporters. One of the major players in …
related to Ca 2+ homeostasis, including Ca 2+ transporters. One of the major players in …
[HTML][HTML] Endoplasmic reticulum refilling and mitochondrial calcium extrusion promoted in neurons by NCX1 and NCX3 in ischemic preconditioning are determinant for …
…, V Valsecchi, C Savoia, GF Di Renzo… - Cell Death & …, 2014 - nature.com
Ischemic preconditioning (IPC), an important endogenous adaptive mechanism of the CNS,
renders the brain more tolerant to lethal cerebral ischemia. The molecular mechanisms …
renders the brain more tolerant to lethal cerebral ischemia. The molecular mechanisms …
HIF‐1α reveals a binding activity to the promoter of iNOS gene after permanent middle cerebral artery occlusion
Hypoxia inducible factor (HIF‐1)‐1α is a specific, oxygen‐sensitive protein that regulates
the activity of HIF‐1, a transcriptional factor that increases after cerebral ischemia and may …
the activity of HIF‐1, a transcriptional factor that increases after cerebral ischemia and may …
Prolactin secretion in man: a useful tool to evaluate the activity of drugs on central 5‐hydroxytryptaminergic neurones. Studies with fenfluramine.
…, U Aguglia, F Scopacasa, GF Direnzo… - British journal of …, 1983 - Wiley Online Library
Acute oral administration of various doses of fenfluramine, a 5‐HT releaser, induced a dose‐related
increase of PRL secretion in nine healthy volunteers. Fenfluramine reached the …
increase of PRL secretion in nine healthy volunteers. Fenfluramine reached the …
[HTML][HTML] Ischemic tolerance modulates TRAIL expression and its receptors and generates a neuroprotected phenotype
…, A Vinciguerra, O Cuomo, GF Di Renzo… - Cell Death & …, 2014 - nature.com
TNF-related apoptosis inducing ligand (TRAIL), a member of the TNF superfamily released
by microglia, appears to be involved in the induction of apoptosis following focal brain …
by microglia, appears to be involved in the induction of apoptosis following focal brain …
NO‐induced neuroprotection in ischemic preconditioning stimulates mitochondrial Mn‐SOD activity and expression via RAS/ERK1/2 pathway
…, LMT Canzoniero, GFD Renzo… - Journal of …, 2007 - Wiley Online Library
To identify the transductional mechanisms responsible for the neuroprotective effect of nitric
oxide (NO) during ischemic preconditioning (IPC), we investigated the effects of this …
oxide (NO) during ischemic preconditioning (IPC), we investigated the effects of this …