Antagonists of nucleic acid derivatives. VIII. Synergism in combinations of biochemically related antimetabolites.
GB Elion, S Singer, GH Hitchings - 1954 - cabidigitallibrary.org
A method is described for representing, either graphically or numerically, synergism between
bacterial antagonists. The effects of various combinations of antagonists of folie acid, …
bacterial antagonists. The effects of various combinations of antagonists of folie acid, …
Metabolic studies of allopurinol, an inhibitor of xanthine oxidase
GB Elion, A Kovensky, GH Hitchings, E Metz… - Biochemical …, 1966 - Elsevier
The metabolic disposition of allopurinol [4-hydroxypyrazolo(3,4-d)-pyrimidine) was determined
in mice, dogs, and human subjects. The drug is a substrate for, as well as an inhibitor of, …
in mice, dogs, and human subjects. The drug is a substrate for, as well as an inhibitor of, …
A comparison of the specificities of xanthine oxidase and aldehyde oxidase
…, SM Neil, GB Elion, GH Hitchings - Archives of Biochemistry …, 1972 - Elsevier
This study directly compares the specificities of the structurally similar hydroxylating enzymes,
aldehyde oxidase and xanthine oxidase. Michaelis-Menten constants for a variety of …
aldehyde oxidase and xanthine oxidase. Michaelis-Menten constants for a variety of …
Potentiation by inhibition of drug degradation: 6-substituted purines and xanthine oxidase
…, H Nathan, S Bieber, RW Rundles, GH Hitchings - Biochemical …, 1963 - Elsevier
The administration of the xanthine oxidase inhibitor. 4-hydroxypyrazolo (3, 4-d)pyrimidine,
concurrently with 6-mercaptopurine, results in a marked decrease in the metabolic oxidation …
concurrently with 6-mercaptopurine, results in a marked decrease in the metabolic oxidation …
Inhibition of folate biosynthesis and function as a basis for chemotherapy
GH Hitchings, JJ Burchall - Adv Enzymol Relat Areas Mol Biol, 1965 - books.google.com
Traditionally, research in chemotherapy has placed primary re—liance on the screening test;
the empirical trial of more-or-less ran-domly selected compounds in a model host—parasite …
the empirical trial of more-or-less ran-domly selected compounds in a model host—parasite …
Studies on condensed pyrimidine systems. IX. The synthesis of some 6-substituted purines
GB Elion, E Burgi, GH Hitchings - Journal of the American …, 1952 - ACS Publications
A variety of 6-aminopurines has been preparedby the reaction of 6-methylmercaptopurine
with aliphatic and aromatic amines. The treatment of hypoxanthine with phosphorus …
with aliphatic and aromatic amines. The treatment of hypoxanthine with phosphorus …
Mechanism of action of trimethoprim-sulfamethoxazole—I
GH Hitchings - Journal of Infectious Diseases, 1973 - academic.oup.com
… Hitchings, GH Daraprim as an antagonist of folic and folinic … K., Hitchings, GH Relative reversal
by vitamins (p-aminobenzoic, folic … Burchall, JJ, Hitchings, GH Inhibitor binding analysis of …
by vitamins (p-aminobenzoic, folic … Burchall, JJ, Hitchings, GH Inhibitor binding analysis of …
[PDF][PDF] Inhibitor binding analysis of dihydrofolate reductases from various species
JJ Burchall, GH Hitchings - Molecular pharmacology, 1965 - Citeseer
Dihydrofolate reductases have been purified approximately 100-fold from Escherichia coil,
Staphylococcus aureus, and Proteus vu!#{231} jarisand to a lesser degree from rat, rabbitr …
Staphylococcus aureus, and Proteus vu!#{231} jarisand to a lesser degree from rat, rabbitr …
Pyrimidine derivatives as antagonists of pteroylglutamic acid.
GH Hitchings, GB Elion, H Vander Werff… - Journal of Biological …, 1948 - cabdirect.org
The stimulating effect of pteroylglutamic acid on the growth of Lactobacillus casei was, in the
absence of purine, inhibited by 2: 4-diaminopyrimidines and 2-aminopyrimidine derivatives. …
absence of purine, inhibited by 2: 4-diaminopyrimidines and 2-aminopyrimidine derivatives. …
Renal clearance of oxipurinol, the chief metabolite of allopurinol
GB Elion, AB Gutman, GH Hitchings - The American journal of medicine, 1968 - Elsevier
Oxipurinol (4,6-dihydroxypyrazolo(3,4-d)pyrimidine; alloxanthine) is the chief metabolite of
allopurinol in vivo. Like allopurinol, although to a lesser degree, oxipurinol suppresses …
allopurinol in vivo. Like allopurinol, although to a lesser degree, oxipurinol suppresses …