User profiles for Giorgio Minotti
Giorgio MinottiProfessore Ordinario di Farmacologia, Universitą Campus Bio-Medico di Roma Verified email at unicampus.it Cited by 18108 |
Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity
The clinical use of anthracyclines like doxorubicin and daunorubicin can be viewed as a sort
of double-edged sword. On the one hand, anthracyclines play an undisputed key role in the …
of double-edged sword. On the one hand, anthracyclines play an undisputed key role in the …
Defining cardiovascular toxicities of cancer therapies: an International Cardio-Oncology Society (IC-OS) consensus statement
…, G Curigliano, JD Mitchell, G Minotti… - European heart …, 2022 - academic.oup.com
The discipline of Cardio-Oncology has seen tremendous growth over the past decade. It is
devoted to the cardiovascular (CV) care of the cancer patient, especially to the mitigation and …
devoted to the cardiovascular (CV) care of the cancer patient, especially to the mitigation and …
[HTML][HTML] The requirement for iron (III) in the initiation of lipid peroxidation by iron (II) and hydrogen peroxide.
The initiation of lipid peroxidation by Fe2+ and H2O2 (Fenton's reagent) is often proposed
to be mediated by the highly reactive hydroxyl radical. Using Fe2+, H2O2, and phospholipid …
to be mediated by the highly reactive hydroxyl radical. Using Fe2+, H2O2, and phospholipid …
[HTML][HTML] Anthracycline cardiotoxicity: from bench to bedside
…, EH Herman, SE Lipshultz, G Minotti… - Journal of clinical …, 2008 - ncbi.nlm.nih.gov
Anthracyclines remain among the most widely prescribed and effective anticancer agents.
Unfortunately, life-threatening cardiotoxicity continues to compromise their usefulness. …
Unfortunately, life-threatening cardiotoxicity continues to compromise their usefulness. …
In Vivo Formation of 8-Epi-Prostaglandin F2α Is Increased in Hypercholesterolemia
…, P Alessandrini, A Mezzetti, G Minotti… - … , and vascular biology, 1997 - Am Heart Assoc
F 2 -isoprostanes are bioactive prostaglandin (PG) -like compounds that are produced from
arachidonic acid through a nonenzymatic process of lipid peroxidation catalyzed by oxygen …
arachidonic acid through a nonenzymatic process of lipid peroxidation catalyzed by oxygen …
An investigation into thee mechanism of citrate FE2+-dependent lipid peroxidation
Chelation by citrate was found to promote the autoxidation of Fe 2+ , measured as the
disapperance of 1,10-phenanthroline-chelatable Fe 2+ . The autoxidation of citrate 2+ could in …
disapperance of 1,10-phenanthroline-chelatable Fe 2+ . The autoxidation of citrate 2+ could in …
The role of iron in the initiation of lipid peroxidation
Iron is required for the initiation of lipid peroxidation. Evidence is presented that lipid peroxidation
requires both Fe 3+ and Fe 2+ , perhaps with oxygen to form a Fe 3+ -dioxygen-Fe 2+ …
requires both Fe 3+ and Fe 2+ , perhaps with oxygen to form a Fe 3+ -dioxygen-Fe 2+ …
Redox cycling of iron and lipid peroxidation
Mechanisms of iron‐catalyzed lipid peroxidation depend on the presence or absence of
preformed lipid hydroperoxides (LOOH). Preformed LOOH are decomposed by Fe(II) to highly …
preformed lipid hydroperoxides (LOOH). Preformed LOOH are decomposed by Fe(II) to highly …
Role of iron in anthracycline cardiotoxicity: new tunes for an old song?
The clinical use of anticancer anthra‐cyclines is limited by the development of a distinctive
and life‐threatening form of cardiomyopathy upon chronic treatment. Commonly accepted …
and life‐threatening form of cardiomyopathy upon chronic treatment. Commonly accepted …
Gamma-glutamyl transpeptidase-dependent iron reduction and LDL oxidation--a potential mechanism in atherosclerosis.
A Paolicchi, G Minotti, P Tonarelli… - … medicine: the official …, 1999 - europepmc.org
Background gamma-Glutamyl transpeptidase (gamma-GT) is found in serum and in the
plasma membranes of virtually all cell types. Its physiologic role is to initiate the hydrolysis of …
plasma membranes of virtually all cell types. Its physiologic role is to initiate the hydrolysis of …