A single gene encodes the key enzyme for estrogen biosynthesis termed aromatase, inhibition
of which effectively eliminates estrogen production. Aromatase inhibitors successfully …

Endometriosis is the most common cause of pelvic pain and affects an estimated 5 million
women in the US. The biologically active estrogen estradiol (E 2 ) is the best-defined mitogen …

Loss of progesterone signaling in the endometrium may be a causal factor in the development
of endometriosis, and progesterone resistance is commonly observed in women with this …

Context: Products of at least five specific steroidogenic genes, including steroidogenic acute
regulatory protein (StAR), which facilitates the entry of cytosolic cholesterol into the …

BACKGROUND: Oral contraceptive pills (OC) are usually the first choice of treatment for
polycystic ovarian syndrome (PCOS), when fertility is not desired. However, they do not improve, …

Aromatase P450 (P450arom) is the key enzyme for biosynthesis of estrogen, which is an
essential hormone for the establishment and growth of endometriosis. There is no detectable …

Endometrial tissue from uterine disease-free women does not exhibit aromatase activity. In
contrast, aromatase enzyme activity and mRNA levels are readily detectable in endometriosis…

Estradiol (E2) stimulates the growth and inflammation in the ectopic endometriotic tissue that
commonly resides on the pelvic organs. Several clinical and laboratory-based observations …

Pathogenesis and growth of three common women's cancers (breast, endometrium and ovary)
are linked to estrogen. A single gene encodes the key enzyme for estrogen biosynthesis …

Local estrogen biosynthesis is a major factor in the pathogenesis of endometriosis. Aberrant
expression of steroidogenic acute regulatory protein (StAR) and aromatase in endometriotic …